3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
LY2119620
CAS: 886047-22-9
Molecular Formula: C19H24ClN5O3S
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide - Names and Identifiers
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide - Physico-chemical Properties
| Molecular Formula | C19H24ClN5O3S |
| Molar Mass | 437.94 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Boling Point | 692.4±55.0 °C(Predicted) |
| pKa | 12.90±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | LY2119620 exhibits mild allosteric agonism, effectively modulating the effects of agonists on functional G protein-signaling at the M2/M4 receptor subtype by placing the M2 and M4 receptors at the active G protein binding site. LY2119620 potentiates the potency of three muscarinic acetylcholine receptor agonists, ACh,Oxo-M, and iperoxo. [3H]LY2119620 can be used as a probe for allosteric binding sites of human M(2) and M(4) muscarinic receptors. |
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.283 ml | 11.417 ml | 22.834 ml |
| 5 mM | 0.457 ml | 2.283 ml | 4.567 ml |
| 10 mM | 0.228 ml | 1.142 ml | 2.283 ml |
| 5 mM | 0.046 ml | 0.228 ml | 0.457 ml |
Last Update：2024-01-02 23:10:35
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide - Reference Information
| biological activity | LY2119620 is a specific allosteric agonist of human M2 and M4 musamino acrine receptors. |
Last Update：2024-04-09 15:16:56
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CAS: 886047-22-9
Tel: 18301782025
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CAS: 886047-22-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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